Table 2. Pre-TAVR laboratories and echocardiography results stratified by STS risk score.
Continuous variables are presented by median (IQR); categorical variables are presented by count (%).
TAVR: transcatheter aortic valve replacement; STS: Society of Thoracic Surgeons; LVEF: left ventricular ejection fraction; HFrEF: heart failure with reduced ejection fraction; AV: aortic valve; PPG: peak pressure gradient; MPG: mean pressure gradient, SPAP: systolic pulmonary artery pressure
*Mixed aortic valve disorder is defined as severe aortic stenosis with an aortic valve regurgitation grade of ≥3.
| Variables | Patients’ STS score | ||||
| All (n=399) | Low risk (n=200) | Intermediate risk (n=136) | High risk (n=63) | P-value | |
| Pre-procedural Laboratories | |||||
| Hemoglobin (g/dL) | 11.7 (10.4-12.9) | 12.2 (11-13.3) | 11.3 (10-12.5) | 11 (9.7-11.8) | <0.01 |
| Creatinine (mg/dL) | 1 (0.8-1.3) | 1 (0.8-1.1) | 1.1 (0.8-1.4) | 1.2 (1-1.9) | <0.01 |
| Pre-procedural Echocardiography | |||||
| LVEF % | 60 (50-65) | 60 (55-65) | 60 (50-60) | 60 (40-65) | 0.377 |
| HFrEF | 84 (22) | 36 (19.7) | 27 (20) | 21 (33.9) | 0.051 |
| Area (cm2) | 0.75 (0.6-0.87) | 0.75 (0.62-0.85) | 0.78 (0.6-0.87) | 0.75 (0.6-0.88) | 0.96 |
| AV PPG (mmHg) | 70.5 (57-81.2) | 71 (59-82.5) | 71 (56-82) | 64 (56-80) | 0.348 |
| AV MPG (mmHg) | 44 (37-53) | 45 (40-54) | 44 (36-51) | 40 (34.5-50) | 0.08 |
| SPAP (mmHg) | 42 (37-53) | 37 (30-50) | 46 (36-58) | 54 (42-68) | <0.001 |
| Mitral regurgitation ≥3 | 35 (9.6) | 10 (5.6) | 15 (11.5) | 10 (16.9) | 0.024 |
| Tricuspid regurgitation ≥3 | 49 (14.2) | 9 (5.6) | 19 (15.1) | 21 (36.8) | <0.001 |
| Aortic Valve Disease | |||||
| Isolated AV stenosis | 344 (87.3) | 180 (91.8) | 116 (85.9) | 48 (76.2) | 0.02 |
| Isolated AV regurgitation | 21 (5.3) | 9 (4.6) | 6 (4.4) | 6 (9.5) | 0.29 |
| Mixed AV disease* | 29 (7.4) | 7 (3.6) | 13 (9.6) | 9 (14.3) | 0.005 |
| Aortic Valve Morphology | |||||
| Tricuspid AV | 355 (89) | 181 (90.5) | 120 (88.2) | 54 (85.7) | 0.54 |
| Bicuspid AV | 7 (1.8) | 5 (2.5) | 2 (1.5) | 0 | 0.6 |
| Bioprosthetic valve | 32 (8) | 11 (5.5) | 13 (9.6) | 8 (12.7) | 0.13 |