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Structure of ADCs. There are three well-defined components: antibody, chemical linker, and cytotoxic payload. Of the current FDA-approved ADCs, all have IgG1 or IgG4 mAbs. Payloads, which either damage DNA or disrupt microtubule formation during mitosis, are linked to the mAb via a chemical linker, which are defined as cleavable or non-cleavable. Created with BioRender.com
