Table 3.
Factors associated with survival
| Univariable analysis | EFS |
OS |
|||
|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | ||
|
| |||||
| Cohort | KU | 0.63 (0.39–0.99) | 0.047 | 0.75 (0.46–1.22) | 0.246 |
| Spanish | 1 | 1 | |||
| Age at diagnosis | < median | 0.86 (0.57–1.31) | 0.483 | 0.89 (0.56–1.40) | 0.599 |
| ≥ median | 1 | 1 | |||
| Race | Non-White | 0.80 (0.37–1.72) | 0.562 | 0.79 (0.34–1.82) | 0.579 |
| White | 1 | 1 | |||
| Menopausal status | Pre | 0.91 (0.60–1.39) | 0.666 | 1.06 (0.67–1.66) | 0.816 |
| Post | 1 | 1 | |||
| Histological grade | 1–2 | 1.49 (0.95–2.34) | 0.085 | 1.38 (0.84–2.27) | 0.197 |
| 3 | 1 | 1 | |||
| T stage | T1–2 | 0.36 (0.24–0.55) | <0.001 | 0.33 (0.21–0.53) | <0.001 |
| T3–4 | 1 | 1 | |||
| Lymph node status | Negative | 0.34 (0.22–0.54) | <0.001 | 0.36 (0.22–0.59) | <0.001 |
| Positive | 1 | 1 | |||
| Germline BRCA1/2 mutation | Yes | 0.91 (0.48–1.73) | 0.782 | 0.89 (0.44–1.79) | 0.743 |
| No | 1 | 1 | |||
| sTILs | ≥ 30% | 0.46 (0.26–0.83) | 0.010 | 0.43 (0.22–0.82) | 0.010 |
| < 30% | 1 | 1 | |||
| Every 5% absolute increase | 0.94 (0.90–0.98) | 0.007 | 0.93 (0.89–0.98) | 0.008 | |
| pCR | Yes | 0.16 (0.09–0.28) | <0.001 | 0.16 (0.09–0.30) | <0.001 |
| No | 1 | 1 | |||
|
| |||||
| Multivariable analysis | EFS |
OS |
|||
| HR (95% CI) | p | HR (95% CI) | p | ||
|
| |||||
| Cohort (KU vs Spanish) | 0.98 (0.57–1.70) | 0.946 | - | - | |
| T stage (T1–2 vs T3–4) | 0.59 (0.36–0.96) | 0.032 | 0.59 (0.34–1.01) | 0.055 | |
| Lymph node status (negative vs positive) | 0.43 (0.26–0.73) | 0.002 | 0.46 (0.26–0.82) | 0.008 | |
| pCR (yes vs no) | 0.20 (0.11–0.37) | <0.001 | 0.20 (0.10–0.39) | <0.001 | |
| sTILs (every 5% absolute increase) | 0.92 (0.83–1.01) | 0.081 | 0.95 (0.90–1.00) | 0.049 | |
T stage and lymph node status are from pre-treatment clinical staging
Menopausal status is not known for n=2 patients
Histological grade is not available for n=20 patients
Lymph node status is not available for n=3 patients
Germline BRCA1/2 status is not available for n=40 patients
sTILs score is not available for n=86 patients
pCR is not known for n=2 patients
Variables that showed association with EFS or OS at p<0.05 in univariable analysis were included in the multivariable model (variables included: cohort, T stage, lymph node status, sTILs, and pCR).
Abbreviations: CI, confidence interval; EFS, event-free survival; HR, hazard ratio; pCR, pathologic complete response, OS, overall survival; sTILs, stromal tumor-infiltrating lymphocytes