Table 1.
Clinicopathologic summary of soft tissue leiomyosarcoma (STLMS)
| Clinicopathologic variables | All cases N (%) | Primary at Presentation N% | Univariate P-value* | Multivariate P-value* |
|---|---|---|---|---|
| Total | 195 | 151 | ||
| Age (years) | 0.511 | |||
| ≤ 60 | 110 (56) | 86 (57) | ||
| > 60 | 85 (44) | 65 (43) | ||
| Sex | 0.489 | |||
| Female | 124 (64) | 96 (64) | ||
| Male | 71 (46) | 55 (36) | ||
| Site | 0.566 | |||
| Retroperitoneal/intraabdominal/pelvic | 145 (74) | 110 (73) | ||
| Extremity | 37 (20) | 31 (21) | ||
| Trunk | 13 (6) | 10 (7) | ||
| Size (cm) | 0.229 | |||
| ≤ 5 | 49 (26) | 46 (31) | ||
| > 5 to ≤ 10 | 77 (41) | 61 (40) | ||
| > 10 | 64 (33) | 44 (29) | ||
| Mitotic rate (per 10 HPF) | 0.0039 | 0.0045 | ||
| ≤ 10 | 96 (49) | 70 (46) | ||
| > 10 to ≤ 20 | 60 (31) | 51 (34) | ||
| > 20 | 39 (20) | 30 (20) | ||
| Necrosis | 0.0371 | 0.2572 | ||
| Present | 134 (81) | 108 (79) | ||
| Absent | 31 (19) | 29 (21) | ||
| Unknown | 30 | 14 | ||
| Progression | ||||
| Yes – Distant metastasis | 171 (88) | 127 (84) | ||
| Yes – Local recurrence | 5 (3) | 5 (3) | ||
| No | 19 (9) | 19 (13) | ||
| Median survival (months) | ||||
| Disease-specific survival | 80.1 | 109 | ||
| Progression-free survival | 26.3 |
*
DSS analysis among 151 STLMS primary at presentation