Table 3.
Postoperative liver injury and the characteristics of postoperative serum alanine aminotransferase elevation in the sevoflurane and propofol groups. Values are expressed as median [inter-quartile range] or number (%).
| Overall patients | Matched patients | |||||
|---|---|---|---|---|---|---|
| Sevoflurane (n = 31,168) | Propofol (n = 13,177) | p-value | Sevoflurane (n = 7767) | Propofol (n = 7767) | p-value | |
| Postoperative liver injury (> 5X ULN) | 501 (1.6) | 238 (1.8) | 0.138 | 112 (1.4) | 124 (1.6) | 0.432 |
| Severity of postoperative ALT elevation | ||||||
| Normal | 21,468 (68.9) | 9639 (73.2) | < 0.001 | 5436 (70.0) | 5941 (76.5) | < 0.001 |
| Borderline elevation (≤ 2X ULN) | 6794 (21.8) | 2427 (18.4) | < 0.001 | 1687 (21.7) | 1246 (16.0) | < 0.001 |
| Mild elevation (≤ 5X ULN) | 2405 (7.7) | 873 (6.6) | < 0.001 | 532 (6.9) | 456 (5.9) | 0.014 |
| Moderate elevation (≤ 15X ULN) | 415 (1.3) | 212 (1.6) | 0.026 | 97 (1.3) | 109 (1.4) | 0.44 |
| Severe elevation (> 15X ULN) | 86 (0.3) | 26 (0.2) | 0.124 | 15 (0.2) | 15 (0.2) | > 0.99 |
| Time to maximal ALT value (days) | 2 [0–7] | 4 [1–7] | < 0.001 | 3 [1–7] | 3 [0–7] | 0.027 |
ALT alanine aminotransferase, ULN upper limit of the normal range.