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. Author manuscript; available in PMC: 2024 May 16.
Published in final edited form as: Trends Endocrinol Metab. 2023 Jan 20;34(3):158–169. doi: 10.1016/j.tem.2023.01.003

Figure 3. The Sensory Pendulum Model of Metabolism integrated with the Deleteriome Model of Aging.

Figure 3.

A greater distance of the pendulum from the point of homeostasis results in an increased deleteriome accumulation. In a biological system, unrestrained pursuit results in disease development, whereas excessive maintenance leads to resource exhaustion. Further progression of disease or exhaustion results in the death of an organism.