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. 2024 May 15;14:11174. doi: 10.1038/s41598-024-61337-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of signalling hubs downstream of JNK1 in mouse brain. (A) JNK1 regulated phosphoproteins from Jnk1-/- mouse brain are organised in a large outer circle with connections to the predicted interacting proteins in the centre. Warmer colours indicate a larger number of physical interactions, red being the highest. (B) Signalling hubs derived from the Jnk1-/- mouse brain phosphoproteome (labelled using gene names) represent the most highly connected phosphoproteins from among all phosphoproteins that are significantly altered in Jnk1-/- brain verses wild-type. For each hub, the distribution of physical interaction count from the 1000 background networks is represented with a boxplot. The number of physical interactions for the same hub in the Jnk1-/- mouse brain phosphoproteome (i.e. the phosphoproteins that are significantly altered in Jnk1-/- mouse brain phosphoproteome), is depicted with a red cross. The most highly ranked JNK1-regulated signalling hubs are shown.