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. 2024 May 15;14:11174. doi: 10.1038/s41598-024-61337-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Testing the effect of JNK1 pathway hub drugs on zebrafish larvae behaviour during the startle period. (A) Zebrafish behaviours are shown during the 1 min startle period following treatment with pharmacological inhibitors or activators of JNK and downstream signalling hubs. As above, drug treatments were for 1 h before exposure to the startle battery. Mean distance, turning, pausing, spurting, time and distance thigmotaxis are shown for the following numbers of fish measurements (5 cycles per zebrafish larvae) SP600125: 224, JNK-IN-8: 346, R18: 354, SC79: 318, AKTi: 360, SB216763: 358, SB590885: 206, FR236924: 360, PMA: 115, BIM: 216, bryostatin-1: 359. P-values were calculated by Wilcoxon Rank Sum test and adjusted with Benjamini–Hochberg procedure and are indicated as follows *p-value ≤ 0.05; **p-value * ≤ 0.01; ***p-value ≤ 0.001; ****p-value ≤ 0.0001.