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. 2024 May 16;14:11177. doi: 10.1038/s41598-024-61865-y

Table 4.

Results of multiple regression analyses with the Hamilton Depression rating Scale (HAMD) score as a dependent variable.

Dependent variables Explanatory variables Parameter estimates Model
β T p F df P R2
#1. HAMD Model 8.94 3/44  < 0.001 0.379
U_CD25+ FOXP3+ CB1+ % −0.460 −3.77  < 0.001
S_CD4+ CD69+ % 0.400 3.28 0.002
U_CD4+ CD40L+ % 0.284 2.38 0.022
#2. HAMD Model 5.85 2/45 0.006 0.206
Age −0.344 −2.59 0.013
S_CD8+ CD40L+ % 0.311 2.34 0.024
#3. HAMD Model 5.91 4/43  < 0.001 0.355
Age −0.401 −3.13 0.003
S_CD8+ CD40L+ MFI 0.341 2.53 0.015
S_CD3+ HLADR+ MFI 0.362 2.65 0.011
S_CD4+ CD69+ MFI 0.270 2.04 0.048
#4. HAMD Model 6.21 4/43  < 0.001 0.366
Age −0.417 −3.29 0.002
S_CD8+ CD40L+ MFI 0.426 3.31 0.002
S_CD3+ HLADR+ MFI 0.373 2.75 0.009
U_CD25+ FOXP3+ CB1+ MFI −0.278 −2.24 0.030
#5. HAMD Model 4.32 1/44 0.044 0.089
U_CD25+ FOXP3+ GARP+ MFI −0.299 −2.99 0.044

% prevalence on immune cell populations, MFI median fluorescence intensity, S stimulated, U unstimulated.