Figure 3.

Bone marrow transfer from AD mice causes cognitive deficits in certain aspects of memory in WT recipient mice

(A) Y maze. A significantly high POA was observed in WT mice as compared to AD animals. AD→WT mice were tested and shown to have no significant difference in percentage alternation as compared to AD mice; however, they showed a significantly lower POA as compared to the WT mice. Data is shown as the mean ± SD and is representative of AD→WT, n = 8 (five males, three females) and WT; n = 11 (six males, five females); and AD, n = 13 (6 males, 7 females). An ordinary one-way ANOVA with Tukey’s multiple comparisons test was used to calculate statistical significance (p ≤ 0.05).

(B and C) RAWM. Both: (B) latency time and (C) the total number of errors were measured. B6/SJL control mice showed a significantly lower latency time and number of errors on day 5 compared to day 1. Although AD→WT animals showed a significantly lower latency time, like the AD mice, they showed no significant difference in the number of errors between test day 1 and test day 5. AD mice showed no difference in the latency time between day 1 and day 5. The data in (B) and (C) are expressed as the mean of the latency time or the total number of errors in a single trial per day by individual animals in each group. Since the difference was being noted on day 1 versus day 5 within each group, a paired t test was used to calculate significance (p ≤ 0.05).