Figure 1.

hESCs with 18q loss show impaired neuroectoderm differentiation

(A) Relative mRNA expression for neuroectoderm markers. Data are shown as means ± SEMs. Each data point refers to an independent differentiation experiment, and ^∗, ^∗∗, ^∗∗∗, and ^∗∗∗∗ represent statistical significance between samples at 5%, 1%, 0.1%, and 0.01%, respectively (unpaired t test).

(B) Immunostaining in mutant and control lines. Scale bars (original images), 50 μm, scale bars (magnification images), 20 μm.

(C) Percentages of PAX6⁺ cells in the immunostainings shown in (B).