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Immune and bone marrow environment changes during the MDS course. Main alterations in low‐risk, high‐risk, or all MDS patients are specified in red, blue, and black, respectively. DC, dendritic cell; IL, interleukin; Ly, lymphocyte; MDS, myelodysplastic neoplasms; MDSC, myeloid‐derived suppressor cell; MSC, mesenchymal stromal cell; NK, natural killer; Th, Helper CD4+ T cell; Treg, regulatory T cell. Dashed lines represent impaired differentiation.
