Table 4.
Table depicting factors influencing overall survival.
| Variable | Median OS in days (95% CI) | Univariate Hazard ratio | Log rank p value | Multivariate Hazard ratio | 95% CI of Hazard ratio | p-value |
|---|---|---|---|---|---|---|
| Age | ||||||
| Age | Not applicablea | 0.99 | Not applicablea | 1.00 | 0.97–1.02 | 0.764 |
| Gender | ||||||
| Male | 64 (34–223) | 0.97 | 0.98 | 1.14 | 0.68–1.91 | 0.630 |
| Female | 104 (43–136) | Reference | ||||
| ECOG PS | ||||||
| 1 | 61 (38–186) | 0.93 | 0.46 | 0.66 | 0.37–1.18 | 0.159 |
| 2–4 | 104 (43–142) | Reference | ||||
| Site | ||||||
| Lung | 90 (47–227) | 0.78 | 0.69 | 0.54 | 0.29–1.014 | 0.055 |
| Non-Lung | 70 (34–128) | Reference | ||||
| Extracranial disease status | ||||||
| Progressive disease | 64 (29–172) | 1.13 | 0.012 | 1.22 | 0.72–2.03 | 0.467 |
| Non-progressive disease | 107 (43–183) | Reference | ||||
| LMC diagnosis | ||||||
| Confirm | 74 (38–142) | 0.81 | 1.000 | 0.43 | 0.23–0.81 | 0.009 |
| Probable | 94 (43–223) | Reference | ||||
| IT received | ||||||
| Yes | 142 (70–245) | 0.69 | 0.13 | 0.35 | 0.19–0.66 | 0.001 |
| No | 51 (29–94) | Reference | ||||
LMC-Leptomeningeal carcinomatosis, ECOG PS- Eastern Cooperative Oncology Group Performance Status, IT-Intrathecal.
a
Continuous variable. Elderly = Age >60 years.