Table 2. Total number of variants (unique) in LitVar 2.0 vs. its original system.

As can be seen, the new system contains significantly more unique variants compared to the original system. This is largely due to the inclusion of supplementary materials in LitVar 2.0 (see Table S3 also). It is also because new published articles on variants have been included since the original system was first published in 2018.

System	Total variants (unique)	Date of Access
LitVar	1,968,872	March 2018
LitVar 2.0	13,829,591	December 2022