Table 1.
Characteristics of severe COVID-19 patients at admission.
| Variable | Normal range | All (n = 87) | Survivors (n = 56) | Non-survivors (n = 31) | p |
|---|---|---|---|---|---|
| Age (years) | 73 (63, 89) | 73.5 (65, 89) | 72 (60, 87.5) | 0.598 | |
| Male/female | 55/32 | 36/20 | 19/12 | 0.964 | |
| White blood cells (×109/L) | 3.5–9.5 | 8.6 (6.4, 13.6) | 7.7 (6.2, 12.5) | 10.3 (7.9, 16.1) | 0.03 |
| Neutrophils (×109/L) | 2.5–7.5 | 7.8 (5.1, 11.4) | 6.3 (4.9, 10.8) | 9.7 (6.8, 14.9) | 0.045 |
| Lymphocytes (×109/L) | 0.8–4 | 0.8 (0.5, 1.1) | 0.8 (0.5, 1.1) | 0.6 (0.4, 1.1) | 0.373 |
| Hemoglobin (g/L) | 115–150 | 93.6 ± 21.2 | 93 ± 22.8 | 94.6 ± 18.2 | 0.72 |
| CRP (mg/L) | 0–4 | 65.4 (26.6, 103.3) | 55.2 (17.6, 81.4) | 103.3 (44.1, 144.4) | < 0.001 |
| TBil (μmoI/L) | 0–21 | 12.0 (7.4–23.4) | 11.2 (7.0–17.5) | 13.5 (10.7–45.7) | 0.072 |
| AST (U/L) | 7–45 | 32.4 (23.2, 84.3) | 29 (22.6, 47.4) | 63.9 (28.9, 170.1) | 0.006 |
| ALT (U/L) | 7–40 | 27.8 (17.7, 50.9) | 23.6 (17.2, 40.4) | 37.9 (20.4, 93) | 0.039 |
| SCr (μmoI/L) | 41–81 | 75.4 (53.8, 156.1) | 67.1 (48.7, 104.8) | 100.8 (70.2, 179.3) | 0.02 |
| PLT (×109/L) | 125–350 | 172 (72.5, 235.5) | 195.5 (105, 247.8) | 120 (64, 194) | 0.048 |
| APTT (s) | 21–37 | 32.7 (29.6, 38.3) | 31.7 (28.7, 35.7) | 37.2 (31.5, 42.9) | 0.002 |
| PT (s) | 9.2–15 | 14.2 (12.8, 15.9) | 13.9 (12.7, 15) | 15.3 (13.6, 20) | 0.002 |
| INR | 0.8–1.25 | 1.2 (1.1, 1.3) | 1.1 (1.1, 1.2) | 1.3 (1.1, 1.7) | 0.002 |
| FIB (g/L) | 2–4 | 4.9 (3.8, 13.5) | 4.8 (3.8, 8.5) | 5.3 (4.1, 13.9) | 0.28 |
| TT (s) | 10–20 | 15.1 (4.6, 16.3) | 14.9 (10.8, 16) | 15.2 (4.1, 17.5) | 0.556 |
| D-Dimer (μg/mL) | 0–0.55 | 2.3 (0.8, 5) | 1 (0.4, 3) | 5.3 (2.7, 16) | <0.001 |
Values are n, mean ± SD, or median (interquartile range), unless otherwise noted. ALT, Alanine aminotransferase; APTT, Activated partial thromboplastin time; AST, Aspartate aminotransferase; CRP, C-reactive protein; FIB, Fibrinogen; HGB, Hemoglobin concentration; INR, International normalized ratio; PLT, Platelet count; PT, Prothrombin time; SCr, Serum creatinine; TBil, Total bilirubin; TT, Thrombin time.