| a) Diagnostic criteria for allergic bronchopulmonary aspergillosis according to Rosenberg et al. [586]: |
|
Main criteria:
|
| 1. Bronchial asthma |
| 2. Positive immediate reaction in the skin test for Aspergillus fumigatus
|
| 3. Total IgE > 417 IU/mL |
| 4. Positive specific IgE against Aspergillus fumigatus
|
| 5. IgG antibodies against Aspergillus fumigatus
|
| 6. Blood eosinophilia (> 1,000 Eos/µL) |
| 7. Central bronchiectasis |
| 8. Radiological volatile or permanent pulmonary infiltrates |
|
Secondary criteria
|
| Tough mucus plugs |
| Positive sputum culture for Aspergillus fumigatus
|
| Late reaction in the intradermal test for Aspergillus fumigatus
|
| b) Modified ISHAM diagnostic criteria for allergic bronchopulmonary aspergillosis 2021 [616]: |
| Combination of criteria with best sensitivity/specificity: |
| 1. Bronchial asthma |
| 2. Aspergillus fumigatus-specific IgE > 0.35 kU/L |
| 3. Total IgE > 500 IU/mL |
| and at least two of the following criteria: |
| 1. Aspergillus fumigatus-specific IgG > 27 mgA/dL |
| 2. Bronchiectasis in CT thorax |
| 3. Eosinophilia in the blood count > 500/µL |
