Table 1.

Two-way ANOVA table

Figure	Factor	F (DFn, DFd)	p value	Multiple comparisons
A	Time	F(1.370,75.35) = 756.4	p < 0.0001	n/a
	Drug	F(3,55) = 5.875	p = 0.0015	1 h, vehicle vs ATR p = 0.0107, vehicle vs AM6545 p = 0.0020, vehicle vs both p < 0.0001; 6 h, vehicle vs AM6545 p = 0020, vehicle vs both p = 0.000; 12 h, vehicle vs AM6545 p = 0.0392, vehicle vs both p = 0.0002
	Time × drug	F(9,165) = 1.851	p = 0.0628	n/a
B	Time	F(1.576,83.01) = 95.51	p < 0.0001	n/a
	Drug	F(3,54) = 0.6320	p = 0.5957	n/a
	Time × drug	F(9,158) = 0.6299	p = 0.7703	n/a
C	Time	F(1.119,61.57) = 344.2	p < 0.0001	n/a
	Drug	F(3,56) = 7.496	p = 0.0003	1 h, vehicle vs both p = 0.0002; 6 h, vehicle vs both p < 0.0001; 12 h, vehicle vs AM6545 p = 0.0061, vehicle vs Both p < 0.0001; 24 h, vehicle vs both p < 0.0001
	Time × drug	F(9,165) = 2.268	p = 0.0202	n/a
D	Time	F(1.617,86.79) = 131.9	p < 0.0001	n/a
	Drug	F(3,56) = 0.9563	p = 0.4156	n/a
	Time × drug	F(9,161) = 0.5702	p = 0.8201	n/a
E	Time	F(1.435,39.70) = 568.4	p < 0.0001	n/a
	Drug	F(1,28) = 1.086	p = 0.3063	n/a
	Time × drug	F(3,83) = 0.5128	p = 0.6746	n/a
F	Time	F(1.632,42.97) = 44.24	p < 0.0001	n/a
	Drug	F(1,28) = 5.920	p = 0.0216	n/a
	Time × drug	F(3,79) = 3.963	p = 0.0110	n/a
G	Time	F(2.070,46.91) = 443.1	p < 0.0001	n/a
	Drug	F(1,24) = 0.3746	p = 0.5462	n/a
	Time × drug	F(3,68) = 0.5729	p = 0.6347	n/a
H	Time	F(1.455,33.47) = 46.34	p < 0.0001	n/a
	Drug	F(1,24) = 0.4416	p = 0.5127	n/a
	Time × drug	F(3,69) = 0.5618	p = 0.6420	n/a
I	Time	F(1.377,38.10) = 456.1	p < 0.0001	n/a
	Drug	F(1,28) = 2.280	p = 0.1423	n/a
	Time × drug	F(3,83) = 0.4852	p = 0.6935	n/a
J	Time	F(1.587,40.73) = 147.1	p < 0.0001	n/a
	Drug	F(1,27) = 1.323	p = 0.2601	n/a
	Time × drug	F(3,77) = 0.4454	p = 0.7212	n/a
K	Time	F(1.643,43.27) = 576.4	p < 0.0001	n/a
	Drug	F(1,28) = 0.2601	p = 0.6141	n/a
	Time × drug	F(3,79) = 0.2981	p = 0.8267	n/a
L	Time	F(1.421,36.94) = 108.9	p < 0.0001	n/a
	Drug	F(1,27) = 0.2764	p = 0.6033	n/a
	Time × drug	F(3,78) = 0.1415	p = 0.9348	n/a