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| rat | dog | |||
|---|---|---|---|---|
| dose (mg/kg) | 0.5 | 0.5 | 1 | 1 |
| rte. of admin. | IVb | POc | IVb | POc |
| CL (mL/min/kg) | 0.729 | 3.96 | ||
| Vss (L/kg) | 0.278 | 0.559 | ||
| Tmax (h) | 1.17 | 0.417 | ||
| T1/2 (h) | 5.1 | 4.36 | 3.56 | 4.8 |
| F% | 81.1 | 78.8 | ||
IV: intravenous injection; PO: oral administration.
10% DMSO, 20% PEG400, 70% Saline.
0.5% CMC-Na in water.
