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Senescent EVs induce a pro-inflammatory and pro-catabolic phenotype in the joints of collagenase-induced OA mice. Relative expression of several markers related to anabolism, catabolism, and inflammation (n = 7/group). Data are shown as mean ± SEM. Statistical analysis used the Mann-Whitney test for comparing samples pairwise with *p < 0.05, **p < 0.01, ***p < 0.001
