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. 2024 May 16;23:105. doi: 10.1186/s12943-024-02010-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Analysis of Melanoma patients’ data from the TCGA database. (A-F) Kaplan-Meier survival analysis of the metastatic Skin Cutaneous Melanoma (SKCM) dataset obtained from TCGA patients’ database. A-D curves were obtained from analysis of the whole TCGA database irrespective of BRAF mutational status (All); E-F curves include only patients with reported BRAF Hotspot Mutations (BRAF-Mut); A, B, E curves were obtained from gene expression database (RNA); C, D, F were obtained from Reverse Phase Protein Array (RPPA) data. Patients were stratified into High and Low RICTOR-expressing groups based on average RNA/Protein expression levels. High-RICTOR/RAPTOR = fourth quartile; Low-RICTOR/RAPTOR = first quartile. Number of patients for each group and p-value calculated by Log-rank test are indicated in individual graphs. (G-H) Dotplots indicate the top 10 most significantly enriched Gene Ontology (GO) categories anticorrelated with RICTOR expression, in the (G) whole dataset (All; n = 367) or (H) after filtering for BRAF Hotspot Mutations (BRAF-Mut; n = 118). NES = Normalized Enrichment Score