Table 1.
Baseline characteristics of the study cohort by cognitive stage. Table denotes mean ± standard deviation for continuous variables and frequency (percentage) for dichotomous variables
| Variables | CU (n = 140) | MCI (n = 78) | Total sample | p | ||
|---|---|---|---|---|---|---|
| Demographics | Mean ± SD | n | Mean ± SD | n | N | |
| Age, years | 65 ± 8 | 140 | 72 ± 7.7 | 78 | 218 | < 0.001 |
| Gender, female | 89 (64%) | 140 | 36 (46%) | 78 | 218 | 0.018 |
| Education, years | 16 ± 4 | 140 | 14 ± 4 | 78 | 218 | 0.002 |
| MMSE | 28.6 ± 1.4 | 140 | 26 ± 2.4 | 78 | 218 | < 0.001 |
| APOE carriers | 36 (28%) | 136 | 38 (49%) | 68 | 204 | < 0.001 |
| Imaging | Mean ± SD | n | Mean ± SD | n | N | |
| Hippocampal volume | 7838 ± 788 | 75 | 6983 ± 996 | 71 | 146 | < 0.001 |
| Amyloid PET positivity | 9 (25%) | 36 | 39 (57%) | 77 | 113 | 0.008 |
| Amyloid Centiloid | 14.5 ± 32.8 | 35 | 41.7 ± 42.8 | 68 | 103 | 0.002 |
| Tau PET positivity | 1 (3%) | 36 | 24 (35%) | 69 | 105 | 0.001 |
| Tau Global SUVR | 1.16 ± 0.14 | 23 | 1.32 ± 0.26 | 57 | 80 | 0.014 |
| Plasma Biomarkers | Mean ± SD | n | Mean ± SD | n | N | |
| Aβ42/Aβ40 | 0.064 ± 0.013 | 140 | 0.059 ± 0.013 | 78 | 218 | 0.009 |
| p-tau181 | 13.2 ± 7 | 140 | 19.9 ± 10 | 78 | 218 | < 0.001 |
| p-tau231 | 7.8 ± 4.1 | 140 | 12.2 ± 6.1 | 78 | 218 | < 0.001 |
| NfL | 15.8 ± 7.9 | 140 | 20.9 ± 9.3 | 78 | 218 | < 0.001 |
| GFAP | 113 ± 55 | 140 | 187 ± 113 | 78 | 218 | < 0.001 |