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Engineered strains S. rimosus ATCC10970∆OTC∆145 kb::OTC with re-located OTC BGC (A) and two S. rimosus ATCC10970∆145 kb strains containing a second copy of the OTC BGC (B). Mean is plotted with error bars showing s.d. (n = 9, three independent fermentations from three biological replicates). Significance is tested by Dunnett’s T3-test, ****P < 0.0001.
