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. 2023 Dec 28;102(3):e207966. doi: 10.1212/WNL.0000000000207966

Table 1.

Univariate Analyses Investigating Differences Between the 2 Groups of Patients With MS In Vivo (Without and With JPRs)

Without JPR (n = 149) With JPR (n = 16) p Value
Age, y, median (IQR) 47.0 (35.0–58.0) 45.0 (32.0–53.2) 0.251
Sex, male, n (%) 60.0 (40.3) 5.0 (31.2) 0.665
Diagnosis, PMS, n (%) 61.0 (40.9) 3.0 (18.8) 0.144
EDSS score, median (IQR) 3.0 (1.5–4.5) 2.3 (1.5–4.5) 0.670
MSSS, median, (IQR) 4.3 (2.6–5.9) 4.8 (3.0–5.7) 0.992
Disease duration, median (IQR) 5.6 (0.8–16.7) 4.5 (0.7–8.7) 0.553
Medication, n (%) 0.568
 Interferon 5.0 (3.7) 0.0 (0.0)
 Copaxone 2.0 (1.5) 0.0 (0.0)
 Dimethyl fumarate 14.0 (10.4) 2.0 (15.4)
 Siponimod 2.0 (1.5) 0.0 (0.0)
 Teriflunomide 5.0 (3.7) 0.0 (0.0)
 Fingolimod 13.0 (9.6) 4.0 (30.8)
 Ocrelizumab 62.0 (45.9) 6.0 (46.2)
 Rituximab 15.0 (11.1) 1.0 (7.7)
 Natalizumab 4.0 (3.0) 0.0 (0.0)
 No therapy at the time of imaging 13.0 (9.6) 0.0 (0.0)
sNfL, pg/mL, median (IQR) 8.6 (6.2–12.6) 9.4 (6.7–16.3) 0.647
sNfL Z score BMI, median (IQR) 0.4 (−0.4, 1.1), 66th percentile 1.0 (0.2–1.5), 83rd percentile 0.108
No. of WML, median (IQR) 40.0 (21.0–71.0) 36.5 (10.7–63.0) 0.509
Total WML volume, mm3, median (IQR) 6,211.0 (2,158.0–15,101.0) 5,611.0 (1,974.0–11,341.7) 0.498
No. of periventricular lesions, median (IQR) 8.0 (4.7–13.0) 9.0 (2.0–10.2) 0.484
Periventricular lesion volume, mm3, median (IQR) 575.0 (186.7–1,467.0) 355.0 (66.7–1,301.7) 0.300
No. of juxtacortical lesions, median (IQR) 31.0 (14.7,56.0) 26.0 (8.7–49.5) 0.485
Juxtacortical lesion volume, mm3, median (IQR) 2,340.0 (744.2–5,560.7) 2,336.0 (820.7–4,241.2) 0.672
No. of cortical lesions, median (IQR) 2.0 (0.0–8.2) 4.0 (1.5–12.0) 0.158
Cortical lesion volume, mm3, median (IQR) 28.5 (0.0–146.0) 128.0 (15.0–352.0) 0.040
No. of leukocortical lesions, median (IQR) 2.0 (0.0–7.0) 3.0 (1.0–10.5) 0.219
Leukocortical lesion volume, mm3, median (IQR) 25.0 (0.0–124.0) 72.0 (13.0–196.0) 0.150
No. of rim-positive WMLs, median (IQR) 2.0 (0.0–6.0) 1.5 (1.0–7.5) 0.086

Abbreviations: EDSS = Expanded Disability Status Scale; IQR = interquartile range; JPR = juxtacortical paramagnetic rim; MSSS = Multiple Sclerosis Severity Score; NfL = neurofilament light chain; PMS = progressive multiple sclerosis; WML = white matter lesion.