Table 1.
Without JPR (n = 149) | With JPR (n = 16) | p Value | |
Age, y, median (IQR) | 47.0 (35.0–58.0) | 45.0 (32.0–53.2) | 0.251 |
Sex, male, n (%) | 60.0 (40.3) | 5.0 (31.2) | 0.665 |
Diagnosis, PMS, n (%) | 61.0 (40.9) | 3.0 (18.8) | 0.144 |
EDSS score, median (IQR) | 3.0 (1.5–4.5) | 2.3 (1.5–4.5) | 0.670 |
MSSS, median, (IQR) | 4.3 (2.6–5.9) | 4.8 (3.0–5.7) | 0.992 |
Disease duration, median (IQR) | 5.6 (0.8–16.7) | 4.5 (0.7–8.7) | 0.553 |
Medication, n (%) | 0.568 | ||
Interferon | 5.0 (3.7) | 0.0 (0.0) | |
Copaxone | 2.0 (1.5) | 0.0 (0.0) | |
Dimethyl fumarate | 14.0 (10.4) | 2.0 (15.4) | |
Siponimod | 2.0 (1.5) | 0.0 (0.0) | |
Teriflunomide | 5.0 (3.7) | 0.0 (0.0) | |
Fingolimod | 13.0 (9.6) | 4.0 (30.8) | |
Ocrelizumab | 62.0 (45.9) | 6.0 (46.2) | |
Rituximab | 15.0 (11.1) | 1.0 (7.7) | |
Natalizumab | 4.0 (3.0) | 0.0 (0.0) | |
No therapy at the time of imaging | 13.0 (9.6) | 0.0 (0.0) | |
sNfL, pg/mL, median (IQR) | 8.6 (6.2–12.6) | 9.4 (6.7–16.3) | 0.647 |
sNfL Z score BMI, median (IQR) | 0.4 (−0.4, 1.1), 66th percentile | 1.0 (0.2–1.5), 83rd percentile | 0.108 |
No. of WML, median (IQR) | 40.0 (21.0–71.0) | 36.5 (10.7–63.0) | 0.509 |
Total WML volume, mm3, median (IQR) | 6,211.0 (2,158.0–15,101.0) | 5,611.0 (1,974.0–11,341.7) | 0.498 |
No. of periventricular lesions, median (IQR) | 8.0 (4.7–13.0) | 9.0 (2.0–10.2) | 0.484 |
Periventricular lesion volume, mm3, median (IQR) | 575.0 (186.7–1,467.0) | 355.0 (66.7–1,301.7) | 0.300 |
No. of juxtacortical lesions, median (IQR) | 31.0 (14.7,56.0) | 26.0 (8.7–49.5) | 0.485 |
Juxtacortical lesion volume, mm3, median (IQR) | 2,340.0 (744.2–5,560.7) | 2,336.0 (820.7–4,241.2) | 0.672 |
No. of cortical lesions, median (IQR) | 2.0 (0.0–8.2) | 4.0 (1.5–12.0) | 0.158 |
Cortical lesion volume, mm3, median (IQR) | 28.5 (0.0–146.0) | 128.0 (15.0–352.0) | 0.040 |
No. of leukocortical lesions, median (IQR) | 2.0 (0.0–7.0) | 3.0 (1.0–10.5) | 0.219 |
Leukocortical lesion volume, mm3, median (IQR) | 25.0 (0.0–124.0) | 72.0 (13.0–196.0) | 0.150 |
No. of rim-positive WMLs, median (IQR) | 2.0 (0.0–6.0) | 1.5 (1.0–7.5) | 0.086 |
Abbreviations: EDSS = Expanded Disability Status Scale; IQR = interquartile range; JPR = juxtacortical paramagnetic rim; MSSS = Multiple Sclerosis Severity Score; NfL = neurofilament light chain; PMS = progressive multiple sclerosis; WML = white matter lesion.