Table 1.
Demographics of ENGAGE and EMERGE Participants With ARIA and Genetic Data
| ARIA-E (N = 529) | ARIA-H microhemorrhage (N = 324) | ARIA-H superficial siderosis (N = 229) | ARIA-H (any) (N = 454) | ARIA (any) (N = 644) | Nonea (N = 1,047) | Full genetic cohort (N = 1,691) | |
| Study | |||||||
| ENGAGE No. (%) | 264 (50) | 153 (47) | 122 (53) | 222 (49) | 313 (49) | 491 (47) | 804 (48) |
| EMERGE No. (%) | 265 (50) | 171 (53) | 107 (47) | 232 (51) | 331 (51) | 556 (53) | 887 (52) |
| Sex, % female | 267 (50) | 167 (52) | 91 (40) | 212 (47) | 322 (50) | 535 (51) | 857 (51) |
| Age, mean (SD) | 70.1 (7.4) | 70.9 (7.2) | 70.4 (7.0) | 70.7 (7.3) | 70.5 (7.4) | 70.1 (7.4) | 70.3 (7.4) |
| APOE genotype, n (%) | |||||||
| ε2/ε2 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ε2/ε3 | 9 (2) | 3 (1) | 4 (2) | 7 (2) | 12 (2) | 24 (2) | 36 (2) |
| ε2/ε4 | 13 (2) | 6 (2) | 4 (2) | 8 (2) | 15 (2) | 19 (2) | 34 (2) |
| ε3/ε3 | 86 (16) | 54 (17) | 22 (10) | 67 (15) | 112 (17) | 354 (34) | 466 (28) |
| ε3/ε4 | 258 (49) | 144 (44) | 113 (49) | 219 (48) | 315 (49) | 527 (50) | 842 (50) |
| ε4/ε4 | 163 (31) | 117 (36) | 86 (38) | 1,553 (34) | 190 (30) | 123 (12) | 313 (19) |
| Dose at ARIA or censor, n (%) | |||||||
| 1 | 2 (<1) | 2 (1) | 1 (<1) | — | — | — | — |
| 3 | 300 (57) | 188 (58) | 122 (53) | — | — | — | — |
| 6 | 106 (20) | 51 (16) | 39 (17) | — | — | — | — |
| 10 | 121 (23) | 83 (26) | 67 (29) | — | — | — | — |
| Radiographic severity, n (%) | — | — | — | ||||
| Mild | 155 (29) | 237 (73) | 113 (49) | ||||
| Moderate | 304 (57) | 41 (13) | 62 (27) | ||||
| Severe | 70 (13) | 46 (14) | 54 (24) | ||||
| Symptomatic ARIA | 133 (25) | 39 (12) | 33 (14) | — | — | — | — |
All participants were of European ancestry and from geographic regions Europe/Canada/Australia and the United States.
a
None = no ARIA-E, ARIA-H microhemorrhage, or ARIA-H superficial siderosis.