Table 2.

Association of APOE Genotypes With ARIA^a,b

APOE genotype	ARIA-E				ARIA-H microhemorrhage				ARIA-H superficial siderosis
	(N = 529 vs 1,162 controls)				(N = 324 vs 1,367 controls)				(N = 229 vs 1,462 controls)
	OR	95% CI	RRc	p Value	OR	95% CI	RRc	p Value	OR	95% CI	RRc	p Value
ε2/ε3	1.47	0.66–3.28	1.37	0.34	0.78	0.23–2.65	0.81	0.69	2.47	0.79–7.7	2.15	0.12
ε2/ε4	2.60	1.23–5.50	2.07	0.01	1.63	0.64–4.17	1.47	0.31	2.64	0.84–8.29	2.27	0.10
ε3/ε4	1.74	1.30–2.31	1.55	0.0002	1.46	1.03–2.06	1.35	0.03	3.14	1.94–5.09	2.59	3.2E-06
ε4/ε4	4.28	3.04–6.02	2.81	6.2E-17	4.58	3.09–6.78	2.85	2.9E-14	7.84	4.67–13.19	4.66	7.8E-15

^aValues are compared with the ε3/ε3 reference group.

^bModels controlled for age at study baseline, sex, study (ENGAGE or EMERGE), last dose level before the ARIA event or censor, and genetic ancestry measured by PCs 1–10.

^cRR was calculated from OR using the equation RR = OR/(1−p₀ + (p₀ × OR)), where p₀ is the baseline risk defined as ε3/ε3 incidence (16% for ARIA-E, 17% for ARIA-H microhemorrhage, 10% for ARIA-H with superficial siderosis).