Table 3.

Association of APOE Genotypes With ARIA Stratified by Radiographic Severity^a,b

ARIA-E
	Mild (N = 146 vs 1,114 controls)				Moderate (N = 295 vs 1,114 controls)				Severe (N = 66 vs 1,114 controls)
APOE genotype	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value
ε3/ε4	1.74	1.11–2.71	1.55	0.02	1.70	1.18–2.46	1.53	0.005	2.09	0.88–4.98	1.78	0.09
ε4/ε4	3.37	1.95–5.82	2.44	1.37E-05	4.19	2.75–6.39	2.77	2.89E-11	7.04	2.83–17.53	3.58	2.72E-05

ARIA-H microhemorrhage
	Mild (N = 230 vs 1,306 controls)				Moderate (N = 39 vs 1,306 controls)				Severe (N = 46 vs 1,306 controls)
APOE genotype	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value
ε3/ε4	1.33	0.91–1.93	1.26	0.14	2.23	0.72–6.9	1.84	0.16	2.60	0.72–9.37	2.04	0.14
ε4/ε4	3.19	2.06–4.93	2.32	1.83E-07	8.27	2.49–27.52	3.70	0.001	21.40	5.99–76.42	4.79	2.38E-06

ARIA-H with superficial siderosis
	Mild (N = 108 vs 1,400 controls)				Moderate (N = 60 vs 1,400 controls)				Severe (N = 53 vs 1,400 controls)
APOE genotype	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value	OR	95% CI	RR	p Value
ε3/ε4	33.30	1.77–6.15	2.68	0.0002	2.11	0.89–5.01	1.90	0.09	6.48	1.5–28.04	4.18	0.01
ε4/ε4	5.00	2.48–10.08	3.57	6.76E-06	8.17	3.34–19.96	4.76	4.05E-06	24.64	5.64–107.68	7.32	2.06E-05

^aValues are compared with the ε3/ε3 reference group.

^bModels controlled for age at study baseline, sex, study (ENGAGE or EMERGE), last dose level before the ARIA event or censor, and genetic ancestry measured by PCs 1–10. ε2/ε3 and ε2/ε4 genotypes were excluded from these analyses because small sample sizes in these groups led to potential model convergence issues.