Table 1.
Test Results for Rabies Virus Diagnostics and Post-Exposure Prophylaxis Biologics
| Sample Type | Date Collected | Reverse-Transcriptase Polymerase Chain Reaction Rabies Virus RNA |
Direct Fluorescent Antibody Rabies Virus Antigen |
IFA RABV Specific IgM |
IFA RABV Specific IgG |
RFFIT RVNA/Titer (CVS.11a) |
RFFIT RVNA/Titer (Minnesota Patient, Silver-Haired Bat Variantb,c) |
|---|---|---|---|---|---|---|---|
| Serum | 15 Jan 2021 | Not detected | Detected | Not detected | Not detected | ||
| CSF | 15 Jan 2021 | Not detected | Detected | Not detected | |||
| CSF | 20 Jan 2021 | Not detected | Detected | Not detected | |||
| Saliva | 21 Jan 2021 | Detected | |||||
| Saliva | 21 Jan 2021 | Indeterminate | |||||
| Skin | 22 Jan 2021 | Not detected | Not detected | ||||
| Brain stem | 23 Jan 2021 | Detected | Detected | ||||
| Vermis | 23 Jan 2021 | Detected | Detected | ||||
| Right cerebellum | 23 Jan 21 | Detected | Detected | ||||
| Left cerebellum | 23 Jan 2021 | Detected | Detected | ||||
| HRIG (hospital) lot no. R2MBD00113 | Detected 1:53 887 (399 IU/mL) | Detected 1:31 950 | |||||
| HRIG (Grifols) lot no. R2MBD00113 | Detected 1:45 687 (366 IU/mL) | Detected 1:33 489 | |||||
| HRIG (Grifols) lot no. R2MFD00163 | Detected 1:67 491 (482 IU/mL) | Detected 1:40 269 | |||||
| Serum (wife) | 2 Feb 2021 | Detected 1:45 (0.33 IU/mL) |
Abbreviations: CSF, cerebrospinal fluid; HRIG, human rabies immunoglobulin; IFA, indirect fluorescent antibody; Ig, immunoglobulin; RABV, rabies virus; RFFIT, rapid fluorescent foci inhibition test; RVNA, rabies virus neutralizing antibodies.
a
Virus dose FFD40 52.
b
Virus dose FFD40 42.
c
Silver-haired bat virus MN Hu A21-0686 P3d4 Snate 2-13-21.