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. Author manuscript; available in PMC: 2024 Oct 13.
Published in final edited form as: Clin Infect Dis. 2023 Oct 13;77(8):1201–1208. doi: 10.1093/cid/ciad098

Table 1.

Test Results for Rabies Virus Diagnostics and Post-Exposure Prophylaxis Biologics

Sample Type Date Collected Reverse-Transcriptase Polymerase
Chain Reaction
Rabies Virus RNA
Direct Fluorescent
Antibody
Rabies Virus Antigen
IFA
RABV Specific
IgM
IFA
RABV Specific
IgG
RFFIT
RVNA/Titer (CVS.11a)
RFFIT
RVNA/Titer (Minnesota Patient,
Silver-Haired Bat Variantb,c)
Serum 15 Jan 2021 Not detected Detected Not detected Not detected
CSF 15 Jan 2021 Not detected Detected Not detected
CSF 20 Jan 2021 Not detected Detected Not detected
Saliva 21 Jan 2021 Detected
Saliva 21 Jan 2021 Indeterminate
Skin 22 Jan 2021 Not detected Not detected
Brain stem 23 Jan 2021 Detected Detected
Vermis 23 Jan 2021 Detected Detected
Right cerebellum 23 Jan 21 Detected Detected
Left cerebellum 23 Jan 2021 Detected Detected
HRIG (hospital) lot no. R2MBD00113 Detected 1:53 887 (399 IU/mL) Detected 1:31 950
HRIG (Grifols) lot no. R2MBD00113 Detected 1:45 687 (366 IU/mL) Detected 1:33 489
HRIG (Grifols) lot no. R2MFD00163 Detected 1:67 491 (482 IU/mL) Detected 1:40 269
Serum (wife) 2 Feb 2021 Detected 1:45 (0.33 IU/mL)

Abbreviations: CSF, cerebrospinal fluid; HRIG, human rabies immunoglobulin; IFA, indirect fluorescent antibody; Ig, immunoglobulin; RABV, rabies virus; RFFIT, rapid fluorescent foci inhibition test; RVNA, rabies virus neutralizing antibodies.

a

Virus dose FFD40 52.

b

Virus dose FFD40 42.

c

Silver-haired bat virus MN Hu A21-0686 P3d4 Snate 2-13-21.