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Genomic analyses of brain tumors for effects of polytherapy on tumor metabolism. (A) Hierarchical clustering of all genes from all the animals treated with saline, cisplatin, or combination therapeutic NPs (abbreviated as polytherapy). Gene expression profiles of (B) mitochondrial genome, (C) fatty acid oxidation–related genes, (D) glycolysis-related genes, (E) OXPHOS-related genes, and (F) apoptotic genes from the different treatment groups compared to saline.
