Fig 2. Variant selection algorithm.

A) Percentage of patients by number of monitorable alterations and by variant status. B) Number of monitorable alterations designed per patient from historical tissue CGP across tumor types based on Foundation Medicine disease classification (See S1 Table for disease mapping). C) PPV of variant selection algorithm at the variant and sample-level. D) Frequency of samples with false positive (FP) variants. Error bars = 90% CI. Abbreviations: crc = colorectal cancer, nsclc = non-small cell lung cancer, cup = cancer of unknown primary (physician specified), gi- gastrointestinal, pns = paranasal sinus, cns = central nervous system, gist = gastrointestinal stromal tumor, FP = false positive, PPV = positive predictive value.