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. Author manuscript; available in PMC: 2024 May 16.
Published in final edited form as: J Allergy Clin Immunol. 2019 Jan 17;143(6):2026–2037.e7. doi: 10.1016/j.jaci.2018.11.049

Figure 4: Effect of HIF inhibitors on Tc2 differentiation.

Figure 4:

The vehicle (DMSO) or inhibitors BAY 87–2243 (BAY) or HIF-C2 were added during CD8+ T cell differentiation. (A) Results of intracellular staining for IL-13 (% positive cells) following SIINFEKL re-stimulation of cells differentiated in IL-2 or IL-2+IL-4 under normoxia or hypoxia. (B) IL-13 protein levels after SIINFEKL re-stimulation of cells differentiated in IL-2 or IL-2+IL-4 under normoxia or hypoxia. Data (means±SEM) are from 5 independent experiments. **p<0.01, compared with cells differentiated DMSO or HIF-C2 in each group.