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. Author manuscript; available in PMC: 2024 May 16.
Published in final edited form as: J Allergy Clin Immunol. 2019 Jan 17;143(6):2026–2037.e7. doi: 10.1016/j.jaci.2018.11.049

Figure 5: IL-13 expression in differentiated HIF-1-α-deficient CD8+ T cells.

Figure 5:

CD8+ T cells from Lck-Cre/OT-1 (WT) and HIF-1α-deficient Lck-Cre/HIF-1αflox/OT-1 (HIF KO) mice were differentiated in vitro in the presence of IL-2 or IL-2 plus IL-4, followed by SIINFEKL restimulation. A, Results (percentage positive) of intracellular staining for IL-13 in cells differentiated in IL-2 plus IL-4 and SIINFEKL restimulation. B, IL-13 protein levels in cells differentiated in IL-2 or IL-2 plus IL-4 under normoxic or hypoxic conditioning after SIINFEKL restimulation. Data (means ± SEMs) are from 5 independent experiments. *P < .05.