Table 1:
Subject Characteristics
| Total | COPD Subtype | ||||
|---|---|---|---|---|---|
| FT | FD | ED | P-Value | ||
| Patient Characteristics | |||||
| Population (n) | 1495 | 189 | 551 | 755 | |
| Age (years) | 62 (8) | 59 (9) | 62 (8) | 64 (8) | <0.0001 |
| Sex (male) | 903 (60) | 105 (56) | 323 (59) | 475 (63) | 0.101 |
| BMI (kg/m2) | 27 (5) | 27 (5) | 29 (6) | 26 (5) | <0.0001 |
| Pulmonary Function | |||||
| FEV1% predicted (%) | 70.4 (24.4) | 88.9 (18.1) | 78.2 (20.6) | 60 (23.5) | <0.0001 |
| FEV1 (L) | 2.1 (0.9) | 2.7 (0.8) | 2.4 (0.8) | 1.8 (0.8) | <0.0001 |
| FVC (L) | 3.5 (1) | 3.7 (1) | 3.6 (1) | 3.3 (1) | <0.0001 |
| FEV1/FVC | 0.59 (0.14) | 0.72 (0.09) | 0.65 (0.11) | 0.53 (0.14) | <0.0001 |
| FEF25–75 (L) | 1.21 (0.95) | 2.01 (1.05) | 1.41 (0.92) | 0.86 (0.77) | <0.0001 |
| GOLD | |||||
| PRISm | 78 (5) | 21 (11.1) | 35 (6.4) | 22 (2.9) | <0.0001 |
| At-Risk | 367 (25) | 114 (60.3) | 163 (29.6) | 90 (11.9) | |
| 1 | 189 (13) | 22 (11.6) | 104 (18.9) | 63 (8.3) | |
| 2 | 488 (33) | 28 (14.8) | 191 (34.7) | 269 (35.6) | |
| 3 | 317 (21) | 4 (2.1) | 52 (9.4) | 261 (34.6) | |
| 4 | 56 (4) | 0 (0) | 6 (1.1) | 50 (6.6) | |
| Clinical Measures | |||||
| Smoking Status (former) | 852 (57) | 81 (43) | 306 (56) | 465 (62) | <0.0001 |
| 6 min Walk Distance (ft) | 1412 (378) | 1525 (370) | 1449 (373) | 1357 (375) | <0.0001 |
| SGRQ Score | 26.8 (21) | 19.3 (18.6) | 22.2 (20) | 32 (21) | <0.0001 |
| TLC (L) | 6.2 (1.4) | 5.7 (1.4) | 6 (1.4) | 6.4 (1.4) | <0.0001 |
| FRC (L) | 3.7 (1) | 2.9 (0.8) | 3.3 (0.8) | 4.1 (1.1) | <0.0001 |
| PRM | |||||
| Normal | 49 (16) | 63 (14) | 57 (10) | 41 (14) | <0.0001 |
| fSAD | 22 (12) | 8 (7) | 17 (8) | 29 (10) | <0.0001 |
| Emph | 7 (9) | 3 (7) | 3 (4) | 11 (10) | <0.0001 |
| PD | 19 (7) | 24 (11) | 20 (7) | 17 (6) | <0.0001 |
Note: Subject characteristics separated total and subsets of those designated fSAD-transition (FT), fSAD-dominant (FD) and emphysema-dominant (ED). Values are displayed as mean (standard deviation). BMI, body mass index; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; FEF25–75, forced expiratory flow at 25–75% of FVC; GOLD, Global Initiative for Chronic Obstructive Lung Disease; PRISm, preserved ratio impaired spirometry; At-risk, at-risk smokers with normal spirometry; TLC, total lung capacity; FRC, functional residual capacity; SGRQ, St. George’s Respiratory Questionnaire; PRM, parametric response map; Norm, Normal; fSAD, functional small airways disease; Emph, emphysema; PD, parenchymal disease.