Table 3.

Univariate and multivariate regression analysis for HF in all subjects

	Univariate		Multivariate model 1		Multivariate model 2
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Sex (male)	0.964 (0.561–1.656)	0.893	0.950 (0.490–1.843)	0.879	—	—
Age	1.199 (0.762–1.886)	0.433	0.862 (0.487–1.526)	0.611	—	—
BMI	0.769 (0.547–1.080)	0.130	0.762 (0.511–1.135)	0.181	—	—
Low systolic BP	1.810 (1.128–2.906)	0.014	1.915 (1.128–3.250)	0.016	1.875 (1.076–3.268)	0.027
Heart rate	3.165 (1.558–6.430)	0.001	3.158 (1.440–6.924)	0.004	3.077 (1.351–7.010)	0.007
Smoking	1.033 (0.638–1.671)	0.896	0.883 (0.449–1.736)	0.719	—	—
Drinking	1.688 (0.919–3.101)	0.091	2.456 (1.097–5.501)	0.029	—	—
Diabetes	1.794 (1.074–2.996)	0.025	1.699 (0.946–3.051)	0.076	—	—
Hyperlipidaemia	0.466 (0.218–0.997)	0.049	0.498 (0.207–1.199)	0.120	—	—
Stroke	0.792 (0.390–1.608)	0.519	0.808 (0.364–1.796)	0.602	—	—
AF	1.055 (0.633–1.758)	0.837	0.740 (0.412–1.330)	0.314	—	—
Coronary disease	0.734 (0.461–1.168)	0.191	0.648 (0.364–1.153)	0.140	—	—
ALT	1.054 (0.672–1.652)	0.819	1.025 (0.614–1.713)	0.924	—	—
Low eGFR	2.239 (1.655–3.029)	<0.001	2.469 (1.731–3.522)	<0.001	2.520 (1.806–3.517)	<0.001
Tyr/Thr tertiles	3.225 (2.307–4.507)	<0.001	—	—	3.510 (2.445–5.040)	<0.001

Model 1, adjusted for conventional HF risk factors; Model 2, adjusted for low systolic BP, heart rate, low eGFR and with the addition of the tertiles of Tyr/Thr.

95% CI, 95% confidence interval; AF, atrial fibrillation; ALT, alanine transaminase; BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; HF, heart failure; OR, odds ratio; Tyr/Thr, tyrosine/threonine.