Table 6.

Cox regression analysis for endpoint in HF subjects

	Unadjusted HR	P value	Adjusted HR	P value
HF endpoint
Tyr/Thr tertiles	1.428 (1.038–1.966)	0.029	1.634 (1.099–2.430)	0.015
Tertile 1	1 (ref)		1 (ref)
Tertile 2	1.208 (0.609–2.396)	0.589	2.146 (0.867–5.312)	0.099
Tertile 3	1.980 (1.053–3.723)	0.034	2.901 (1.228–6.851)	0.015
CV death
Tyr/Thr tertiles	2.452 (1.402–4.287)	0.002	2.887 (1.417–5.884)	0.004
Tertile 1	1 (ref)		1 (ref)
Tertile 2	1.243 (0.334–4.627)	0.746	3.320 (0.546–20.200)	0.193
Tertile 3	4.675 (1.572–13.899)	0.006	8.908 (1.703–46.590)	0.010
HF readmission
Tyr/Thr tertiles	1.432 (1.041–1.971)	0.027	1.653 (1.112–2.457)	0.013
Tertile 1	1 (ref)		1 (ref)
Tertile 2	1.215 (0.612–2.411)	0.577	2.211 (0.894–5.470)	0.086
Tertile 3	1.992 (1.059–3.746)	0.032	2.982 (1.262–7.048)	0.013

Adjusted for sex, age, BMI, low systolic BP, heart rate, smoking, drinking, DM, hyperlipidaemia, stroke, AF, coronary disease, ALT, low eGFR, hsCRP, and NT‐proBNP.

CV, cardiovascular; HF, heart failure; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein; Tyr/Thr, tyrosine/threonine.