Table 1.

Selected Characteristics of High Causality Pregnancy-associated DILI Cases

Case #	Age (y)	Race/Ethnicity	Implicated Drug	DILI Onset	Weeks Gestation at onset	Pattern of Injury	Causality Score	Severity Score	Maternal Outcome	Fetal Outcome	Peak ALT U/L	Peak TB mg/dL
1	43	W	Methyldopa	Pregnancy	10	HC	Definite	Moderate Hospitalized	Resolution	Unknown	2459	11
2	29	B	Methyldopa	Pregnancy	20	HC	Highly Likely	Mild	Resolution	Miscarriage	800	0.8
3	30	B	Methyldopa	Pregnancy	8	HC	Highly Likely	Moderate Hospitalized	Resolution	Unknown	1315	17.8
4	24	B	Infliximab	Pregnancy	22	HC	Highly Likely	Severe	Resolution	Delivered	1155	25.41
5	20	W	Quetiapine	Pregnancy	29	HC	Highly Likely	Mild	Resolution	Delivered	1078	0.4
6	34	H	Isoniazid	Pregnancy	1st trimester	HC	Probable	Severe/Fatal	Transplant	Miscarriage	2095	13.8
7	28	W	Letrozole	Pregnancy	NA	HC	Probable	Moderate	Resolution	Miscarriage	827	7
8	28	B	Methyldopa	Postpartum	-	HC	Highly Likely	Severe	Resolution	Delivered	579	21.7
9	20	W	OCP	Postpartum	-	HC	Highly Likely	Moderate Hospitalized	Resolution	Delivered	445	14.9
10	32	H	Methyldopa	Postpartum	-	HC	Definite	Severe	Resolution	Delivered	1415	29.9
11	28	W	Cefazolin	Postpartum	-	C	Highly Likely	Moderate Hospitalized	Resolution	Terminated	201	7.3
12	25	B	Methyldopa	Postpartum	-	HC	Highly Likely	Moderate Hospitalized	Resolution	Delivered	1292	24.9
13	39	B	Methyldopa	Postpartum	-	HC	Highly Likely	Moderate Hospitalized	Resolution	Delivered	1414	19.5
14	26	W	Methyldopa	Postpartum	-	HC	Highly Likely	Moderate Hospitalized	Resolution	Delivered	1577	15.3
15	31	H	PTU	Pregnancy	36	M	Probable	Severe	Resolution	Delivered	549	8.4
16	31	B	Methyldopa	Pregnancy	11	HC	Probable	Moderate Hospitalized	Unknown	Unknown	1481	3.2

Definite causality score corresponds to >95% likelihood, high likely= 70-95%, probable= 50-<70%. Abbreviations: W=White, B=Black, H= Hispanic, HC=Hepatocellular, C=Cholestatic, PTU=propylthiouracil; OCP, oral contraceptive pills.