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. 2024 Apr 10;26(5):784–796. doi: 10.1038/s41556-024-01401-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Red blood cell (RBC), hemoglobin concentration (HGB), hematocrit (HCT), in peripheral blood at 3 to 4 weeks of age were analysed. (mean ± s.e.m., RBC and HCT: n = 11 for wild-type, n = 9 for Adh5^+/−Aldh2^+/KI, n = 8 for Adh5^−/−Aldh2^+/KI, n = 7 for Adh5^−/−Aldh2^KI/KI, n = 10 for Adh5^−/−Csb^−/−, n = 13 for Adh5^+/−Aldh2^+/KICsb^−/−, n = 4 for Adh5^+/−Aldh2^KI/KICsb^−/−, n = 9 for Adh5^−/−Aldh2^+/KICsb^−/−, HGB: n = 7 for wild-type, n = 9 for Adh5^+/−Aldh2^+/KI, n = 8 for Adh5^−/−Aldh2^+/KI, n = 6 for Adh5^−/−Aldh2^KI/KI, n = 6 for Adh5^−/−Csb^−/−, n = 12 for Adh5^+/−Aldh2^+/KICsb^−/−, n = 4 for Adh5^+/−Aldh2^KI/KICsb^−/−, n = 8 for Adh5^−/−Aldh2^+/KICsb^−/−). Statistical significance was evaluated with Dunnett’s multiple comparison test. P compared to Adh5^−/−Aldh2^+/KICsb^−/− mice. (b) Quantification of hematopoietic subset: LKS (Lin⁻c-Kit⁺Sca-1⁺), MPP (Lin⁻c-Kit⁺Sca-1⁺CD150⁻CD48⁻), HPC1 (Lin⁻c-Kit⁺Sca-1⁺CD150⁻CD48⁺), HPC2 (Lin⁻c-Kit⁺Sca-1⁺CD150⁺CD48⁺), CLP (Lin⁻c-Kit^lowSca-1^lowCD127⁺CD135⁺), CMP (Lin⁻c-Kit⁺Sca-1⁻CD34⁺CD16/32⁻), MEP (Lin⁻c-Kit⁺Sca-1⁻CD34⁻CD16/32⁻), and GMP (Lin⁻c-Kit⁺Sca-1⁻CD34⁺CD16/32⁺) in mice at 3 to 4 weeks of age is shown (means ± s.e.m.; n = 7 for wild-type, n = 6 for Adh5^+/−Aldh2^+/KI, n = 6 for Adh5^−/−Aldh2^+/KI, n = 3 for Adh5^−/−Aldh2^KI/KI, n = 7 for Adh5^−/−Csb^−/−, n = 4 for Adh5^+/−Aldh2^+/KICsb^−/−, n = 5 for Adh5^+/−Aldh2^KI/KICsb^−/−, n = 4 for Adh5^−/−Aldh2^+/KICsb^−/−). Statistical significance was evaluated with Dunnett’s multiple comparison test. P compared to Adh5^−/−Aldh2^+/KICsb^−/− mice. Source numerical data are available in source data.