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. 2024 Mar 28;26(5):698–709. doi: 10.1038/s41556-024-01393-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, HES1, EOMES and NEUN immunostaining in human cerebral organoid at week 8. b, Distribution of division modes identified in bRG cells within week 8–11 cerebral organoids. bRG daughter (EOMES− and NEUN−), differentiating daughter (EOMES+ or NEUN+) (N = 276 bRG cells from three batches of organoids). c, Live/fixed correlative analysis of an asymmetrically dividing bRG cell revealing HES1 expression specifically in self-renewing daughter (EOMES− and NEUN−). d, Summary of HES1 expression in daughter cells depending on division modes (N = 239 cells from three batches of organoids). e, Live/fixed correlative analysis in asymmetrically dividing bRG cells revealing lack of correlation between HES1 expression and basal process inheritance. f, Summary of HES1 expression depending on process inheritance in asymmetrically dividing bRG cells, within week 8–11 cerebral organoids (N = 16 cells from three batches of organoids). All images are representative examples of experiments performed in at least three independent organoid batches.