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. 2024 Apr 4;143(5):625–634. doi: 10.1007/s00439-024-02670-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Number of predicted functional impacts annotated by each tool over time. Tools with ≥ 3 predictions are labeled. The x-axis shows the day of publication in MEDLINE. The y-axis shows the number of predicted functional impacts in the most recent version of the tool. The grey line represents the least squares regression line. The light grey shaded area surrounding this line represents the 95% pointwise confidence intervals. The flat black line represents the quantile regression line at the median