Table 5.

Relationship between baseline MRI measures and SDMT performance at baseline and over the follow-up in pwRRMS.

T2-FLAIR measures		SDMT at baseline	Absolute SDMT change	T1-WI based measures		SDMT at baseline	Absolute SDMT change
T2-LV	r-value	−0.326	−0.079	WBV	r-value	0.321	0.048
	p-value	<0.001	0.172		p-value	<0.001	0.417
LVV	r-value	−0.265	−0.083	GMV	r-value	0.263	0.007
	p-value	<0.001	0.154		p-value	<0.001	0.9
Thalamic volume	r-value	0.287	0.135	Thalamic volume	r-value	0.312	0.119
	p-value	<0.001	0.016		p-value	<0.001	0.043
Thalamic dysconnectivity	r-value	−0.327	−0.048
	p-value	<0.001	0.409

pwRRMS-people with relapsing-remitting multiple sclerosis; FLAIR – Fluid-attenuated inversion recovery, WI-weighted imaging; SDMT – Symbol Digit Modalities Test, LVV – lateral ventricular volume, LV – lesion volume, WBV – whole brain volume, GMV – gray matter volume.

The relationships were determined using non-parametric Spearman’s rank correlation test.

P-values lower than 0.05 were considered statistically significant and shown in bold.