Table 2.
Median values of the highest quality studies in anal disease annual rate parameters
| Parameter | Median value (low, high)a | Reference |
|---|---|---|
| Cure rate of distant anal cancer | 0.3630 (–) | Bernard-Tessier et al. [47] |
| Rate of distant anal cancer-associated death | 0.1683 (0.1405, 0.2024) | Kim et al. [48] |
| Rate of local anal cancer-associated death | 0.1090 (0.1055, 0.1124) | Baricevic et al. [49] |
| Rate of progression from AIN 1 to AIN 2/3 | 0.4542 (0.1726, 0.7224) | Liu et al. [50] |
| Rate of progression from CIS 2 to local anal cancer | 0.0093 (0.0066, 0.0241) | Faber et al. [51] |
| Rate of progression from local to regional anal cancer | 0.1107 (0.0279, 0.1935) | Oehler-Jänne et al. [52] |
| Rate of progression from regional to distant anal cancer | 0.0269 (0.0189, 0.0349) | Oehler-Jänne et al. [52] |
| Rate of regression from AIN 1 to persistently infected | 0.0984 (–) | Scholefield et al. [53] |
| Rate of regression from AIN 2/3 to persistently infected | 0.3750 (0.1700, 0.5800) | Mathews et al. [54] |
AIN anal intraepithelial neoplasia, CIS carcinoma in situ
aRates are in units of 1/years. For parameters with only one value reported in their high-quality study, the ranges were represented as “(–)”