Table 4.

Median values of the highest quality studies in vulvar disease annual rate parameters

Parameter	Median value (low, high)a	References
Cure rate for both treated and untreated VIN 1	0.9463 (0.8379, 1.0548)	Westermann et al. [60]
Rate of local vulvar cancer-associated death	0.0397 (–)	Kortekaas et al. [61]
Rate of progression from CIS 2 to local vulvar cancer	0.0102 (0.0086, 0.0693)	Thuijs et al. [62]
Rate of regression from VIN 1 to recovered or persistent HPV	1.7312 (–)	Jones et al. [63]
Recurrence rate of treated VIN 1	0.0636 (–)	Kortekaas et al. [61]

CIS carcinoma in situ, HPV human papillomavirus, VIN vulvar intraepithelial neoplasia

^aRates are in units of 1/years. For parameters with only one value reported in their high-quality study, the ranges were represented as “(–)”