Table 9.
Median values of the highest quality studies for performance of detection tests of human papillomavirus (HPV)-related cancers
| Anatomical location | Parameter | Accuracy measure | Median value (low, high)a | References |
|---|---|---|---|---|
| Cervical | Detection rate of CIN 1 | PPV (%) | 24.8 (4.3, 60.1) | Leinonen et al. [86] |
| Cervical | Detection rate of CIN 1 | Sensitivity (%) | 57.4 (34.4, 76.6) | Giorgi Rossi et al. [87] |
| Cervical | Detection rate of CIN 1 | Specificity (%) | 97.1 (84.4, 99.6) | Leinonen et al. [86] |
| Cervical | Detection rate of CIN 2 | NPV (%) | 97.3 (91.2, 100.0) | Cuzick et al. [88] |
| Cervical | Detection rate of CIN 2 | PPV (%) | 28.1 (24.4, 31.6) | Ogilvie et al. [89] |
| Cervical | Detection rate of CIN 2 | Sensitivity (%) | 78.0 (43.7, 94.4) | Giorgi Rossi et al. [87] |
| Cervical | Detection rate of CIN 2 | Specificity (%) | 71.4 (57.7, 95.6) | Giorgi Rossi et al. [87] |
| Cervical | Detection rate of CIN 3 | NPV (%) | 99.1 (96.8, 100.0) | Cuzick et al. [88] |
| Cervical | Detection rate of CIN 3 | PPV (%) | 13.9 (11.0, 16.7) | Ogilvie et al. [89] |
| Cervical | Detection rate of CIN 3 | Sensitivity (%) | 80.6 (51.4, 100.0) | Giorgi Rossi et al. [87] |
| Cervical | Detection rate of CIN 3 | Specificity (%) | 77.2 (26.9, 94.0) | Gage et al. [90] |
| Cervical | Detection rate of CIS 1 and CIS 2 | Sensitivity (%) | 100.0 (–) | Granados et al. [91] |
| Cervical | Detection rate of local cervical cancer | NPV (%) | 97.7 (97.1, 98.3) | De Strooper et al. [92] |
| Cervical | Detection rate of local cervical cancer | PPV (%) | 5.4 (4.4, 6.4) | De Strooper et al. [92] |
| Cervical | Detection rate of local cervical cancer | Sensitivity (%) | 54.3 (40.0, 68.6) | De Strooper et al. [92] |
| Cervical | Detection rate of local cervical cancer | Specificity (%) | 67.4 (65.1, 69.8) | De Strooper et al. [92] |
| Cervical | Detection rate of a colposcopy to detect CIN or higher | Sensitivity (%) | 91.2 (–) | Mandal et al. [93] |
| Vaginal | Detection rate of a colposcopy to detect VAIN or higher | Sensitivity (%) | 17.5 (0.0, 96.6) | Zhou et al. [94] |
| Vulvar | Detection rate of a colposcopy to detect VIN or higher | Sensitivity (%) | 98.0 (–) | Santoso et al. [95] |
CIN cervical intraepithelial neoplasia, CIS carcinoma in situ, NPV negative predictive value, PPV positive predictive value, VAIN vaginal intraepithelial neoplasia, VIN vulvar intraepithelial neoplasia
aFor parameters with only one value reported in their high-quality study, the ranges were represented as “(–)”