Figure 3.

Cross-sectional associations with difference in serum NfL levels per SD higher plasma log-sphingolipid concentrations, N = 2,061. Cer, ceramide; CI, confidence interval; FDR, false discovery rate; NfL, neurofilament light chain; SD, standard deviation; SM, sphingomyelins; 16, 20, 22, and 24 stand for the number of carbons of the saturated fatty acid acylated to the sphingolipid backbone. Linear regression beta coefficients adjusted for age, sex, race/ethnicity, education, field center, year of blood sample measurement, BMI, physical activity, alcohol intake, smoking status, depression score, prevalent diabetes, prevalent coronary heart disease, prevalent hypertension, lipid-lowering medication use, HDL-cholesterol, LDL-cholesterol and mutual adjustment of sphingolipids with 16-carbon fatty acid chains with corresponding sphingolipids with 22-carbon fatty acid chains and sphingolipid with 20-, 22-, 24-carbon fatty acid chains with sphingolipids with 16-carbon fatty acid chains (Model 3).