Table 1.

Adjusted odds ratios for increase in number of brain infarcts per SD higher plasma log-sphingolipid concentrations in sex-stratified analysis.

Sphingolipid	OR for increase in number of brain infarcts (95% CI)
	Women (N = 1,175)			Men (N = 785)
	Model 3	P-value		Model 3	P-value
		Unadjusted	FDR		Unadjusted	FDR
Cer-16	0.97 (0.82, 1.15)	0.74	0.82	1.11 (0.90, 1.36)	0.34	0.75
Cer-20	1.26 (1.07, 1.49)	0.004	0.03	1.06 (0.88, 1.28)	0.50	0.75
Cer-22	1.14 (0.96, 1.37)	0.14	0.22	0.96 (0.77, 1.20)	0.75	0.75
Cer-24	0.98 (0.83, 1.16)	0.82	0.82	0.87 (0.71, 1.07)	0.14	0.75
SM-16	1.15 (0.96, 1.37)	0.05	0.10	1.03 (0.82, 1.29)	0.71	0.75
SM-20	0.83 (0.69, 0.99)	0.03	0.09	1.09 (0.89, 1.34)	0.40	0.75
SM-22	0.92 (0.77, 1.10)	0.38	0.50	0.94 (0.75, 1.17)	0.57	0.75
SM-24	0.82 (0.70, 0.98)	0.03	0.09	0.90 (0.73, 1.12)	0.34	0.75

Cer, ceramide; CI, confidence interval; FDR, false discovery rate; OR, odds ratio; SM, sphingomyelins; 16, 20, 22, and 24 stand for the number of carbons of the saturated fatty acid acylated to the sphingolipid backbone. Model 3 adjusted for age, sex, race/ethnicity, education, field center, year of blood sample measurement, BMI, physical activity, alcohol intake, smoking status, depression score, prevalent diabetes, prevalent coronary heart disease, prevalent hypertension, lipid-lowering medication use, HDL-cholesterol, and LDL-cholesterol, mutual adjustment of sphingolipids with 16-carbon fatty acid chains with sphingolipids with 22-carbon fatty acid chains and sphingolipids with 20-, 22-, 24-carbon fatty acid chains with sphingolipids with 16-carbon fatty acid chains. Cer-20, P for sex interaction = <0.001.