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. 2024 May 3;15:1371667. doi: 10.3389/fmicb.2024.1371667

Figure 3.

Figure 3

Gut microbiota affects male reproductive function in four dimensions. (1) Gut microbiota affects male fertility via four facets. And probiotics supplementation is proved to have pharmaceuticals value for male infertility. (2) Substances from dashed oval box in blue represent those that can be secreted or indirectly elevated by the gut microbiota, and red are reduced. (3) Abbreviations: SCFAs: short chain fatty acids; PUFAs: polyunsaturated fatty acids; BCAAs: branched chain amino acids; 5-HT: 5-hydroxytryptamine; IGF-1: insulin-like growth factor-1; LPS: lipopolysaccharide; GLP-1: glucagon-like peptide-1; ACTH: adrenocorticotropic hormone. (3) Within the dashed boxes are aspects of the impact of the gut microbiota on male reproductive function. HPT axis: hypothalamic-pituitary-testis axis; HSDH: hydroxysteroid dehydrogenase; BTB: the blood-testes barrier.