Table 2.

Heterogeneity and multiplicity analysis of metformin and outcomes.

Exposure	Outcome	Method	Q	Q P value	egger_intercept	P value	MR-PRESSO P value
Metformin	MI	MR Egger	23.67	0.050	-2.15550e-04	0.464	0.075
		IVW	24.63	0.055
	Old MI	MR Egger	52.60	0.072	-3.88839e-05	0.68	0.09
		IVW	52.84	0.083
	Acute MI	MR Egger	37.90	0.428	-8.28776e-05	0.235	0.409
		IVW	39.40	0.407
	Acute transmural MI of anterior wall	MR Egger	13.00	0.966	1.59961e-05	0.768	0.970
		IVW	13.09	0.975
	Acute transmural MI of anterior wall	MR Egger	35.72	0.298	-7.95372e-06	0.898	0.395
		IVW	35.74	0.341

MI, myocardial infarction; IVW, inverse variance-weighted; MR, Mendelian randomization; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier.