Table 1.
Summary of demographics and C-reactive protein measurement across six diverse cohorts
| Sample | N | Age (years), mean, SD | Sex, N female, % female | CRP (mg/L), mean, SD | CRP assay | DNAm assay (Illumina) |
|---|---|---|---|---|---|---|
| ALSPAC | ||||||
| Age 0 | 389 | – | 198, 50.1 | 0.2, 0.9 | high sensitivity | 450 K array |
| Age 9 | 336 | 9.8, 0.3 | 163, 48.5 | 0.6, 1.1 | high sensitivity | 450 K array |
| Age 15 or 17 | 945 | 17.1, 1.1 | 492, 52.1 | 1.1, 1.8 | high sensitivity | 450 K array |
| Age 24 | 745 | 24.5, 0.8 | 365, 49.0 | 1.7, 2.5 | high sensitivity | 450 K array |
| Mothers (follow-up) | 773 | 47.8, 4.3 | 773, 100 | 1.8, 2.2 | high sensitivity | 450 K array |
| Generation Scotland | ||||||
| Whole sample | 17,936 | 47.5, 14.9 | 10,536, 58.7 | 3.3, 2.9 | high sensitivity | EPIC array |
| HELIOS | ||||||
| Chinese ethnicity | 1,778 | 54.6, 11.8 | 729, 61.9 | 1.5, 3.8 | wide range | EPIC array |
| Malay ethnicity | 242 | 55.4, 11.1 | 148, 61.2 | 2.9, 4.9 | wide range | EPIC array |
| Indian ethnicity | 225 | 51.3, 11.8 | 126, 56.0 | 4.4, 7.6 | wide range | EPIC array |
| SABRE | ||||||
| European ethnicity | 315 | 69.9, 6.3 | 0, 0 | 3.6, 7.9 | high sensitivity | 450 K array |
| South Asian ethnicity | 273 | 69.3, 6.2 | 0, 0 | 2.7, 3.8 | high sensitivity | 450 K array |
| LBC1936 | ||||||
| Age 70 (W1) | 885 | 69.6, 0.8 | 439, 49.6 | 5.3, 6.9 | low sensitivity | 450 K array |
| Age 73 (W2) | 756 | 72.5, 0.7 | 361, 47.8 | 3.0, 5.5 | high sensitivity | 450 K array |
| Age 76 (W3) | 536 | 76.3, 0.7 | 258, 48.1 | 3.1, 4.8 | high sensitivity | 450 K array |
| Age 79 (W4) | 492 | 79.3, 0.6 | 240, 48.8 | 2.5, 5.6 | high sensitivity | 450 K array |
| LBC1921 | ||||||
| Age 87 (W3) | 170 | 86.6, 0.4 | 92, 54.1 | 5.5, 7.2 | low sensitivity | 450 K array |
| Age 90 (W4) | 49 | 90.2, 0.1 | 29, 59.2 | 8.4, 11.7 | low sensitivity | 450 K array |
Low-sensitivity assays could not reliably detect values below 3 mg/L. These values were set to 1.5 mg/L in line with previous LBC publications8 and may have contributed to altered distribution properties at time points and cohorts that used low-sensitivity platforms. ALSPAC, Avon Longitudinal Study of Parents and Children; CRP, C-reactive protein; DNAm, DNA methylation; HELIOS, Health for Life in Singapore; LBC, Lothian Birth Cohort; SABRE, Southall and Brent Revisited; SD, standard deviation; W, wave.