Figure 3.
Quantitative complementation of four genes at two QTLs on chromosome 4 for contextual fear conditioning
(A and C) QTL regional information from LocusZoom.59 The top part shows the association results from a meta-analysis, with the position of the highest-scoring variant annotated in purple. The vertical scale is the negative logarithm (base 10) of the association p value. The bottom section gives the location and orientation of genes at the locus. A red box identifies each gene used in the quantitative complementation tests.
(B and D) Results of quantitative complementation testing of six annotated genes. The vertical axis is the quantile normalized duration of freezing to the context from the fear-conditioning test. The horizontal axis lists the groups of mice used. Groups are B6.WT: WT C57BL/6J; B6.KO: heterozygote KOs on C57BL/6J; D2.WT: F1 from crossing DBA/2J to C57BL/6J; D2.KO: the F1 from crossing the KO onto DBA/2J. Genes significant by quantitative complementation are shown in gray (results in Table 1).