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. 2024 May 1;4(5):100545. doi: 10.1016/j.xgen.2024.100545

Figure 4.

Figure 4

Quantitative complementation of three genes at three QTLs for the number of entries into the open arms of the EPM

(A, C, and E) QTL regional information from LocusZoom.59 The top part shows the association results from a meta-analysis, with the position of the highest-scoring variant annotated in purple. The vertical scale is the negative logarithm (base 10) of the association p value. The bottom section gives the location and orientation of genes at the locus. A red box identifies each gene used in the quantitative complementation tests.

(B, D, and F) Results of quantitative complementation testing. The vertical axis is the quantile normalized duration of the number of entries into the open arms of the elevated plus maze. The horizontal axis lists the groups of mice used. Groups are B6.WT: WT C57BL/6J; B6.KO: heterozygote KOs on C57BL/6J; D2.WT: F1 from crossing DBA/2J to C57BL/6J; D2.KO: the F1 from crossing the KO onto DBA/2J.